Friday, March 11, 2011

Active principle content and isozymes of Andrographis paniculata Nees (Kalmegh)

Abstract
Germplasm collection of Andrographis paniculata Nees (Kalmegh), a medicinal herb endowed with curative properties against a variety of ailments, was carried out from various parts of south Asia. The germplasm was reared in a field plot under identical conditions and then seeds were collected and used for the present study. Seed progenies of 15 accessions were analysed at 15 loci representing 8 enzyme systems. On an average 5.4 loci (36.00%) were found to be polymorphic (P) and mean observed number of alleles per locus (A) was 1.41. Average observed heterozygocity (Ho) was 0.406 and expected value (He) was 0.233 showing moderate level of genetic variation among different accessions. Product synthesis did not correlate with allelic variations in any of the accessions but an accession AP36 accumulating significant concentration (1.47% dry weight) of andrographolide in the leaves may be potentially useful for breeding and cultivar development.

Published in:
Journal of Medicinal and Aromatic Plant Sciences 23 (2001) 637-647.

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